NHR Science

Bergamonte - Organic Bergamot Extract for Heart & Cardiovascular Health

$38.95

NHR Science

Bergamonte - Organic Bergamot Extract for Heart & Cardiovascular Health

$38.95

Bergamonte® contains citrus bergamot - a proprietary extract of citrus bergamia risso which grows almost exclusively in the narrow coastal Calabria region of Southern Italy.  Backed by 12 published human clinicals, Bergamonte® has been clinically tested to maintain healthy HDL, LDL, triglycerides, and glucose levels already in normal range, providing superior support for healthy cardio metabolic function.*

  • Supports Healthy Cholesterol and Glucose Levels Already in the Normal Range*
  • Maintain a Healthy Heart & Cardiovascular Function*
  • Supports Healthy Weight Management & Metabolic Wellness*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Comprehensive Cardiovascular Protection with Support for Your Cholesterol Profile

Citrus Bergamot contains Bergamonte®– a proprietary extract of Citrus bergamia Risso which grows almost exclusively in the narrow coastal Calabria region of Southern Italy. Bergamonte® provides a superior full spectrum antioxidant potency with ORAC 5.0 value of >22,000 umole TE/g.

Bergamonte® Benefits:

  • Helps Maintain a Healthy Heart & Cardiovascular Function*
  • Helps Support Healthy Cholesterol and Glucose Levels Already in the Normal Range*
  • Revitalizes youthful AMPK levels*
  • Promotes healthy balance of hormones responsible for hunger & satiety*
  • Assists in Sustaining Healthy Weight Management*
  • Support Healthy Cardiometabolic Function*
  • Provides Powerful Antioxidant Protection*

Bergamonte® Helps Safeguard Vascular and Heart Health

Backed by 12 published human clinicals, Bergamonte® has been clinically tested to provide superior support for healthy cardio metabolic function, and help maintain healthy HDL, LDL, triglycerides, and glucose levels already in normal range*.

Balancing good (HDL) and bad (LDL) cholesterol is a key part of supporting a healthy blood lipid profile.   Bergamonte® promotes HDL-C production and help support optimal HDL/LDL ratios already within normal range*.

Bergamonte® Activates AMPK

Bergamonte® BPE Complex stimulate AMPK, master regulator of metabolic pathways that regulates healthy glucose, lipid metabolism and energy production. As we age, AMPK activity significantly decline, that is one reason why we experience changes in appetite, body weight, energy levels, and increase in accumulation of abdominal fat.  Studies showed that taking Bergamonte® BPE-C can help revitalize youthful AMPK levels, supports already-healthy cholesterol levels and glucose level, support healthy vascular function, help burn fat, and promote healthy cellular metabolism.*

Bergamonte® Scavenges Free Radicals & Provides Superior Antioxidant Protection

Bergamonte® provides superior antioxidant protection with ORAC 5.0 value of >28,500 umole TE/g.  That means 1 serving (2 capsules) of Bergamonte® is equivalent to the ORAC value of > 6 servings of fruits, since average servings of fruits provide about 2,186 ORAC.  Bergamonte® supports the body's capacity to scavenge reactive oxygen species and supports cellular antioxidant defense against damaging free radicals.

Bergamonte® Encourages Autophagy

Autophagy is the body’s natural process for cleaning out intra-cellular debris and other metabolic waste, so that newer & healthier cells can regenerate.  As we age, our bodies get less adept at autophagy, the natural process for recycling cellular debris slowed and result in accumulation of damaged and senescent cells.   This can trigger inflammatory pathways and contribute to various health imbalances.  The polyphenols in Bergamonte® encourages autophagy process, promotes the pathway to recycle waste material, maintains cellular energy balance, and helping your body function optimally.

Bergamonte® Promotes Healthy Inflammatory Response

Bergamonte® helps support the body’s inflammatory response, maintains the balance between cytokine compounds that your body needs to function harmoniously, and encourages healthy C-reactive protein levels already within the normal range*

Bergamonte® Promotes Healthy Endothelial Function

In addition to maintaining already-healthy cholesterol levels, Bergamonte® is also clinically shown to support endothelial function, promotes already-healthy levels of blood glucose, insulin and blood pressure,  thus helping to maintain healthy circulation*. Flavanoids in Bergamot have been shown to protect against LDL oxidation and favorably promote endothelial function, thus helping to maintain healthy circulation*.

Research-Backed Results

What sets Bergamonte® apart is that the ingredient has been tested by double-blind randomized controlled studies, 12 published human clinicals and counting!!!  This is the Bergamot extract used in the published study.  Bergamonte® has been clinically shown to provide superior support for healthy cardio metabolic function, help maintain healthy HDL, LDL, triglycerides already in normal range, and support healthy endothelial function.  Clinical evidence also demonstrates that it promotes healthy balance of hormones responsible for hunger & satiety, promotes already-healthy levels of blood glucose, insulin and blood pressure.  Try and experience the Bergamonte® difference!

Bergamonte® is a registered trademark of HP Ingredients Corporation. 

SUGGESTED USE: Take 1000mg of Citrus Bergamot daily during the first 1 to 6 months until optimal healthy cholesterol is achieved; 500mg to 1000mg as maintenance daily usage thereafter, or as directed by your qualified healthcare professional.

Bergamot is a plant that produces a type of citrus fruit. Oil from the peel of the fruit, and extract from the fruit juice, are used to make medicine. Bergamot is used for high levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia).
 

 

OTHER INGREDIENTS: Vegetarian capsules (Hydroxypropyl Methylcellulose), Non-GMO Rice Flour.

NO artificial colors, flavors or preservatives. NO wheat, gluten, soy, dairy, egg, corn, yeast, fish/shellfish, peanuts or tree nuts. Non-GMO

 

Bergamonte Published Human Clinicals

 

  1. Hypolipemic and hypoglycaemic activity of bergamot polyphenols: From animal models to human studies

Fitoterapia Volume 82, Issue 3, April 2011, Pages 309-316

Vincenzo Mollace, Iolanda Sacco, Elzbieta Janda, Claudio Malara, Domenica Ventrice, Carmen Colica, Valeria Visalli, Saverio Muscoli, Salvatore Ragusa, Carolina Muscoli, Domenicantonio Rotiroti, Franco Romeo

https://www.sciencedirect.com/science/article/abs/pii/S0367326X10002777?via%3Dihub

 

  1. Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDLcholesterol, LOX-1 expression and Protein Kinase B phosphorylation in patients with hyperlipidemia

International Journal of Cardiology   November 14, 2013

Micaela Gliozzi, Ross Walker, Saverio Muscoli, Cristiana Vitale, Santo Gratteri, Cristina Carresi,

Vincenzo Musolino, Vanessa Russo, Elzbjeta Janda, Salvatore Ragusa, Antonio Aloe, Ernesto

Palma, Carolina Muscoli, Franco Romeo and, Vincenzo Mollace

https://www.internationaljournalofcardiology.com/article/S0167-5273(13)01708-7/fulltext

 

  1. The Effect of Bergamot-Derived Polyphenolic Fraction on LDL Small Dense Particles and Non Alcoholic Fatty Liver Disease in Patients with Metabolic Syndrome

Advances in Biological Chemistry Jan 2014

Micaela Gliozzi, Cristina Carresi, Vincenzo Musolino, Ernesto Palma, Carolina Muscoli, Cristiana Vitale, Santo Gratteri, Giuseppe Muscianisi, Elzbieta Janda, Saverio Muscoli, Francesco Romeo, Salvatore Ragusa, Rocco Mollace, Ross Walker, James Ehrlich, Vincenzo Mollace*

https://www.researchgate.net/publication/275990261_The_Effect_of_Bergamot-Derived_Polyphenolic_Fraction_on_LDL_Small_Dense_Particles_and_Non_Alcoholic_Fatty_Liver_Disease_in_Patients_with_Metabolic_Syndrome#:~:text=In%20conclusion%2C%20our%20data%20confirm,derivatives%20in%20reducing%20cardiometabolic%20risk.

 

  1. Atherogenic Index Reduction and Weight Loss in Metabolic Syndrome Patients Treated with A Novel Pectin-Enriched Formulation of Bergamot Polyphenols

Nutrients 2019, 11, 1271

Antonio Soccorso Capomolla, Elzbieta Janda, Sara Paone, Maddalena Parafati, Tomasz Sawicki, Rocco Mollace, Salvatore Ragusa and Vincenzo Mollace

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627641/

 

  1. Synergistic in vitro antioxidant activity and observational clinical trial of F105, a phytochemical formulation including Citrus bergamia, in subjects with moderate cardiometabolic risk factors

Canadian Journal of Physiology and Pharmacology  Volume 94, Number 12, December 2016

John G. Babish, Clinton J. Dahlberg, Joseph J. Ou, William J. Keller, Wei Gao, Mohan R. Kaadige,

Holly Brabazon, Joseph Lamb, Hani C. Soudah, Xiaolan Kou, Zhe Zhang, Linda M. Pacioretty,

and Matthew L. Tripp

https://www.nrcresearchpress.com/doi/full/10.1139/cjpp-2016-0062#.XxG7nShKgdU

 

  1. A 13-week low glycemic load diet and lifestyle modification program combining low glycemic load protein shakes and targeted nutraceuticals improved weight loss and cardio-metabolic risk factors

Canadian Journal of Physiology and Pharmacology   Volume 95, Number 12, December 2017

Clinton J. Dahlberg, Joseph J. Ou, John G. Babish, Joseph J. Lamb, Sarah Eliason, Holly Brabazon,

Wei Gao, Mohan R. Kaadige, and Matthew L. Tripp

https://www.nrcresearchpress.com/doi/full/10.1139/cjpp-2016-0704?src=recsys#.XxG8jShKgdU

 

  1. Effects of 12-week supplementation of Citrus bergamia extracts-based formulation CitriCholess on cholesterol and body weight in older adults with dyslipidemia: a randomized, double-blind, placebo controlled trial

Lipids in Health & Disease 2017 Dec 22;16(1):251.

Yong Cai, Guoqiang Xing, Tian Shen, Shuxian Zhang, Jianyu Rao and Rong

https://pubmed.ncbi.nlm.nih.gov/29273027/

 

  1. Three‐arm, placebo‐controlled, randomized clinical trial evaluating the metabolic effect of a combined nutraceutical containing a bergamot standardized flavonoid extract in dyslipidemic overweight subjects

Phytotherapy Research Aug 2019 Volume33, Issue8

Arrigo Francesco Giuseppe Cicero, Federica Fogacci, Marilisa Bove, Marina Giovannini, Claudio Borghi

https://onlinelibrary.wiley.com/doi/epdf/10.1002/ptr.6402

 

  1. Low-Dose of Bergamot-Derived Polyphenolic Fraction (BPF) Did Not Improve Metabolic Parameters in Second Generation Antipsychotics-Treated Patients: Results from a 60-days Open-Label Study

Frontier Pharmacology . 2017 Apr 11;8:197.

Antonio Bruno, Gianluca Pandolfo, Manuela Crucitti, Massimo Cacciola, Vincenza Santoro, Edoardo Spina, Rocco A. Zoccali and Maria R. A. Muscatello

https://pubmed.ncbi.nlm.nih.gov/28443024/

 

  1. Bergamot Polyphenolic Fraction Supplementation Improves Cognitive Functioning in Schizophrenia. Data From an 8-Week, Open-Label Pilot Study

Journal of Clinical Psychopharmacology: August 2017 - Volume 37 - Issue 4 - p 468-471

Antonio Bruno, MD, PhD, Gianluca Pandolfo, MD, PhD, Manuela Crucitti, MD, Clemente Cedro, MD, PhD,

Rocco Antonio Zoccali, MD, and Maria Rosaria Anna Muscatello, MD, PhD

https://journals.lww.com/psychopharmacology/Abstract/2017/08000/Bergamot_Polyphenolic_Fraction_Supplementation.17.aspx

 

  1. The Hepatic Effects of Citrus Bergamot Polyphenol Fraction (BPF) on Patients with Non-alcoholic Fatty Liver Disease and Metabolic Syndrome

Journal of Clinical Lipidology, Vol 9, No 3, June 2015

James E. Ehrlich, MD Michaela Gliozzi, PhD Elzbieta Janda, PhD Ross Walker, MD Vincenzo Mollace, MD, PhD

https://www.lipidjournal.com/article/S1933-2874(15)00171-3/pdf

 

  1. Citrus Bergamot Improves Atherogenic Lipoprotein Particle Characteristics in Patients With Non-alcoholic Fatty Liver Disease and Metabolic Syndrome

Journal of Clinical Lipidology, Vol 9, No 3, June 2015

James E. Ehrlich, MD Michaela Gliozzi, PhD Elzbieta Janda, PhD Ross Walker, MD Vincenzo Mollace, MD, PhD

https://www.lipidjournal.com/article/S1933-2874(15)00186-5/pdf

 

Review Papers for Cholesterol, Metabolic Syndrome, NAFLD

  1. Clinical application of bergamot (Citrus bergamia) for reducing high cholesterol and cardiovascular disease markers

Mirielle C Nauman and Jeremy J Johnson

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497409/

 

  1. The Role of Nutraceuticals in Statin Intolerant Patients

Maciej Banach, MD, PHD, Angelo Maria Patti, MD, Rosaria Vincenza Giglio, BS, Arrigo F.G. Cicero, MD, PHD

Atanas G. Atanasov, PHD  Gani Bajraktari, MD, PHD, Eric Bruckert, MD, PHD, Olivier Descamps, MD, PHD,,

https://www.onlinejacc.org/content/72/1/96#:~:text=Nutraceuticals%20can%20be%20natural%20alternatives,blood%20pressure%2C%20inflammation%2C%20and%20oxidative

 

  1. Bergamot Polyphenols: Pleiotropic Players in the Treatment of Metabolic Syndrome

Micaela Gliozzi, Ross Walker and Vincenzo Mollace

https://www.hilarispublisher.com/open-access/bergamot-polyphenols-pleiotropic-players-in-the-treatment-2167-0943.1000143.pdf

 

 

In-Vitro In-Vivo Research

  1. Anti-inflammatory and Antioxidant Effects of Flavonoid-Rich Fraction of Bergamot Juice (BJe) in a Mouse Model of Intestinal Ischemia/Reperfusion Injury

Daniela Impellizzeri, Marika Cordaro, Michela Campolo, Enrico Gugliandolo, Emanuela Esposito, Filippo Benedetto, Salvatore Cuzzocrea, and Michele Navarra

https://www.frontiersin.org/articles/10.3389/fphar.2016.00203/full

 

  1. Anti-oxidant effect of bergamot polyphenolic fraction counteracts doxorubicin-induced cardiomyopathy: Role of autophagy and ckitpos CD45neg CD31neg cardiac stem cell activation

Cristina Carresi, Vincenzo Musolino, Micaela Gliozzi, Jessica Maiuolo, Rocco Mollace, Saverio Nucera, Alessia Maretta, Domenico Sergi, Saverio Muscoli, Santo Gratteri, Ernesto Palma, Francesca Bosco, Caterina Giancotta, Carolina Muscoli, Fabiola Marino, Iolanda Aquila, Daniele Torella, Franco Romeo, Vincenzo Mollace

https://www.jmmc-online.com/article/S0022-2828(18)30108-1/fulltext

 

  1. Qualitative and quantitative analysis of the Proautophagic activity of Citrus flavonoids from Bergamot Polyphenol Fraction

Elzbieta Janda, Raffaele Salerno, Concetta Martino, Antonella Lascala, Daniele LaRussa, Manuela Oliverio

https://www.sciencedirect.com/science/article/pii/S2352340918306450

 

  1. Bergamot Polyphenols Boost Therapeutic Effects of the Diet on Non-Alcoholic Steatohepatitis (NASH) Induced by “Junk Food”: Evidence for Anti-Inflammatory Activity

Maddalena Parafati, Antonella Lascala, Daniele La Russa, Chiara Mignogna, Francesca Trimboli, Valeria Maria Morittu, Concetta Riillo, Rachele Macirella, Vincenzo Mollace, Elvira Brunelli and Elzbieta Janda

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267059/

 

  1. Treatment With a Flavonoid-Rich Fraction of Bergamot Juice Improved Lipopolysaccharide-Induced Periodontitis in Rats

Enrico Gugliandolo, Roberta Fusco, Ramona D’Amico, Matteo Peditto, Giacomo Oteri, Rosanna Di Paola, Salvatore Cuzzocrea and Michele Navarra

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345201/

 

  1. Efficacy of bergamot: From anti-inflammatory and anti-oxidative mechanisms to clinical applications as preventive agent for cardiovascular morbidity, skin diseases, and mood alterations

Simone Perna Daniele Spadaccini Leonardo Botteri Carolina Girometta, Antonella Riva Pietro Allegrini Giovanna Petrangolini Vittoria Infantino, Mariangela Rondanelli

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392855/

 

  1. Oxidative Imbalance and Kidney Damage in Cafeteria Diet-Induced Rat Model of Metabolic

Syndrome: Effect of Bergamot Polyphenolic Fraction

Daniele La Russa, Francesca Giordano, Alessandro Marrone, Maddalena Parafati,

Elzbieta Janda and Daniela Pellegrino

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466566/

 

  1. The effect of bergamot polyphenolic fraction on lipid transfer protein system and vascular oxidative stress in a rat model of hyperlipemia

Vincenzo Musolino, Micaela Gliozzi, Saverio Nucera, Cristina Carresi, Jessica Maiuolo, Rocco Mollace,

Sara Paone, Francesca Bosco, Federica Scarano, Miriam Scicchitano, Stefano Ruga, Maria Caterina Zito,

Carmen Colica, Roberta Macrì, Ernesto Palma, Salvatore Ragusa, Carolina Muscoli and

Vincenzo Mollace

https://lipidworld.biomedcentral.com/track/pdf/10.1186/s12944-019-1061-0

 

  1. Antioxidant and Antisenescence Effects of Bergamot Juice

Eleonora Da Pozzo, Marinella De Leo, Immacolata Faraone, Luigi Milella, Chiara Cavallini, Eugenia Piragine, Lara Testai, Vincenzo Calderone, Luisa Pistelli, Alessandra Braca, and Claudia Martini 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079356/

 

  1. Bergamot natural products eradicate cancer stem cells (CSCs) by targeting mevalonate, Rho-GDI-signaling and mitochondrial metabolism

Marco Fiorillo, Maria Peiris-Pagès, Rosa Sanchez-Alvarez, Lucia Bartella, Leonardo Di Donna, Vincenza Dolce, Giovanni Sindona, Federica Sotgia, Anna Rita Cappello, Michael P. Lisanti

https://www.sciencedirect.com/science/article/pii/S0005272818300616?via%3Dihub

 

  1. Inhibition of Spinal Oxidative Stress by Bergamot Polyphenolic Fraction Attenuates the Development of Morphine Induced Tolerance and Hyperalgesia in Mice

Filomena Lauro, Luigino Antonio Giancotti, Sara Ilari, Concetta Dagostino,

Micaela Gliozzi, Chiara Morabito, Valentina Malafoglia, William Raffaeli,

Maurizio Muraca, Bianca M. Goffredo, Vincenzo Mollace, Carolina Muscoli

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881894/

 

  1. Anti-inflammatory and Antioxidant Effects of Flavonoid-Rich Fraction of Bergamot Juice (BJe) in a Mouse Model of Intestinal Ischemia/Reperfusion Injury

Daniela Impellizzeri, Marika Cordaro, Michela Campolo, Enrico Gugliandolo,

Emanuela Esposito, Filippo Benedetto, Salvatore Cuzzocrea and Michele Navarra

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945634/

 

  1. Anti-Inflammatory Activity of Citrus bergamia Derivatives: Where Do We Stand?

Nadia Ferlazzo, Santa Cirmi, Gioacchino Calapai, Elvira Ventura-Spagnolo,

Sebastiano Gangemi and Michele Navarra

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274179/