ParActin® Andrographis Human Clinical Trials

1. Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial

Clinical Rheumatology volume 28, pages931–946(2009)  R. A. Burgos, J. L. Hancke, J. C. Bertoglio, V.

Aguirre, S. Arriagada, M. Calvo & D. D. Cáceres

https://link.springer.com/article/10.1007/s10067-009-1180-5

1. Andrographolide a New Potential Drug for the Long Term Treatment of Rheumatoid Arthritis Disease

Innovative Rheumatology Jan 2013.    

María A. Hidalgo, Juan L. Hancke, Juan C. Bertoglio and Rafael A. Burgos

https://www.intechopen.com/books/innovative-rheumatology/andrographolide-a-new-potential-drug-for-the-long-term-treatment-of-rheumatoid-arthritis-disease

1. Andrographis paniculata decreases fatigue in patients with relapsing-remitting multiple sclerosis: a 12-month double-blind placebo-controlled pilot study

BMC Neurology volume 16, Article number: 77 (2016).  J. C. Bertoglio, M. Baumgartner, R. Palma, E. Ciampi, C. Carcamo, D. D. Cáceres, G. Acosta-Jamett, J. L. Hancke & R. A. Burgos

https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-016-0595-2

1. A double‐blind, randomized, placebo‐controlled study to assess the efficacy of Andrographis paniculata standardized extract (ParActin®) on pain reduction in subjects with knee osteoarthritis

Phytotherapy Research.  Volume33, Issue5 May 2019 Pages 1469-1479. 

Juan L. Hancke  Shalini Srivastav  Dante D. Cáceres  Rafael A. Burgos

https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.6339

1. Efficacy of Andrographolide in Not Active Progressive Multiple Sclerosis: A Prospective Exploratory Double-Blind, Parallel-Group, Randomized, Placebo-Controlled Trial

BMC Neurology (2020) 20:173.  Ethel Ciampi, Reinaldo Uribe-San-Martin, Claudia Cárcamo, Juan Pablo Cruz, , Ana Reyes, Diego Reyes, Carmen Pinto, Macarena Vásquez, Rafael A. Burgos and Juan Hancke

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203851/pdf/12883_2020_Article_1745.pdf

Andrographis Immune Health Research

1. A Double Blind Study with a New Monodrug: Kan Jang Decrease of Symptoms and Enhancement of Resistance to Common Colds.

Phototherapy Research 9: 559- 562, 1995.  JL. Hancke et al.

1. Prevention of common colds with Andrographis paniculata dried extract: A Pilot double blind trial

Phytomed. 4 (2), 101-104 (1997).  D.D. Cáceres et al.

https://www.sciencedirect.com/science/article/abs/pii/S0944711397800517?via%3Dihub

1. Use of visual analogue scale measurements (VAS) to asses the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomized double blind-placebo study

Phytomedicine Volume 6, Issue 4, October 1999, Pages 217-223.  D.D.Cáceres, J.L.Hancke, R.A.Burgos, F.Sandberg, G.K.Wikman

https://www.sciencedirect.com/science/article/abs/pii/S0944711399800129?via%3Dihub

1. Andrographolide As a Potential Inhibitor of SARS-CoV-2 Main Protease: An In Silico Approach

Journal of Biomolecular Structure and Dynamics, Apr 2020. Sukanth Kumar Enmozhi, Kavitha Raja, Irudhayasamy Sebastine, Tiruchirappalli, & Jerrine Joseph

https://www.tandfonline.com/doi/full/10.1080/07391102.2020.1760136

1. Andrographis paniculata (Chuān Xīn LiaÂn) for symptomatic relief of acute respiratory tract infections in adults and children: A systematic review and meta-analysis

PLoS One. 2018; 13(11).  Xiao-Yang Hu, Ruo-Han Wu, Martin Logue, Clara Blondel, Lily Yuen Wan Lai, Beth Stuart, Andrew Flower, Yu-Tong Fei, Michael Moore, Jonathan Shepherd, Jian-Ping Liu, and George Lewith

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235384/

1. Immunomodulatory activity of andrographolide on macrophage activation and specific antibody response.

Acta Pharmacol Sin. 2010 Feb; 31(2): 191–201. Wei Wang, Jing Wang, Sheng-fu Dong, Chun-hong Liu, Paola Italiani, Shu-hui Sun, Jing Xu, Diana Boraschi, Shi-ping Ma, and Di Qu

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002847/

Andrographis Anti-Viral Research

1. Activity of Andrographolide and Its Derivatives against Influenza Virus in Vivo and in Vitro

Biological and Pharmaceutical.  Volume 32 (2009) Issue 8

Jian-Xin Chen, Hui-Jun Xue, Wen-Cai Ye, Bing-Hu Fang, Ya-Hong Liu, Shao-Hua Yuan, Pei Yu, Yu-Qiang Wang

https://www.jstage.jst.go.jp/article/bpb/32/8/32_8_1385/_article

1. A Phase I Trial of Andrographolide in HIV Positive Patients and Normal Volunteers

Phytotherapy Research. Volume14, Issue5 August 2000

Pages 333-338.  Carlo Calabrese  Sheryl H. Berman  John G. Babish  Xinfang Ma  Lynne Shinto  Melissa Dorr  Kameron Wells  Cynthia A. Wenner  Leanna J. Standish

https://onlinelibrary.wiley.com/doi/abs/10.1002/1099-1573(200008)14:5%3C333::AID-PTR584%3E3.0.CO;2-D

1. Activity of andrographolide against chikungunya virus infection

Scientific Report. 2015; 5: 14179.  Phitchayapak Wintachai, Parveen Kaur, Regina Ching Hua Lee, Suwipa Ramphan, Atichat Kuadkitkan, Nitwara Wikan, Sukathida Ubol, Sittiruk Roytrakul, Justin Jang Hann Chu, and Duncan R. Smith

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585663/

1. Broad-spectrum antiviral properties of andrographolide

Archives of Virology 162(3) · November 2016.  Swati Gupta, K. P. Mishra.

https://www.researchgate.net/publication/311098110_Broad-spectrum_antiviral_properties_of_andrographolide

1. Analyzing the interaction of a herbal compound Andrographolide from Andrographis paniculata as a folklore against swine flu (H1N1)

Asian Pac J Trop Dis. 2014 Sep; 4: S624–S630.  Chandrabhan Seniya, Shilpi Shrivastava, Sanjay Kumar Singh, and Ghulam Jilani Khan

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129870/

1. Antiviral and Immunostimulant Activities of Andrographis paniculata

HAYATI Journal of Biosciences 22(2) · April 2015.    Churiyah, Elrade Rofaani, Olivia Bunga Pongtuluran 

https://www.researchgate.net/publication/307707579_Antiviral_and_Immunostimulant_Activities_of_Andrographis_paniculata

1. Possible inhibitors of ACE2, the receptor of 2019-nCoV

Pharmacology & Toxicology February 2020.  Qinghua Cui, Chuanbo Huang, Xiangwen Ji, Wanlu Zhang, Fenghong Zhang, Liang Wang

https://www.preprints.org/manuscript/202002.0047/v1

1. Computational Investigation on Andrographis paniculata Phytochemicals to Evaluate Their Potency Against SARS-CoV-2 in Comparison to Known Antiviral Compounds in Drug Trials.

JOURNAL OF BIOMOLECULAR STRUCTURE AND DYNAMICS May 2020. 

Natarajan Arul Murugan, Chitra Jeyaraj Pandian and Jeyaraman Jeyakanthan

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309306/pdf/TBSD_A_1777901.pdf

1. Crosstalk Between Endoplasmic Reticulum Stress and Anti-Viral Activities: A Novel Therapeutic Target for COVID-19.

Life Science 2020 Aug 15; 255: 117842. 

Aditi Banerjee, Steven J. Czinn, Russel J. Reiter, and Thomas G. Blanchard

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245231/

Andrographis Lung Health Research

1. Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity

British Journal of Pharmacology.  Volume168, Issue7 April 2013 Pages 1707-1718.

SP Guan,  W Tee,  DSW Ng,  TK Chan,  HY Peh,  WE Ho,  C Cheng,  JC Mak,  WSF Wong

https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.12054

1. Andrographolide Protects against LPS-Induced Acute Lung Injury by Inactivation of NF-kB

PLoS One. 2013; 8(2).  Tao Zhu, Dao-xin Wang, Wei Zhang, Xiu-qing Liao, Xian Guan, Hong Bo, Jia-yang Sun,  Ni-wen Huang, Jing He, Yun-kun Zhang, Jing Tong, and Chang-yi Li

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578846/

1. Cigarette Smoke-Induced Lung Disease Predisposes to More Severe Infection with Nontypeable Haemophilus influenzae: Protective Effects of Andrographolide

Journal of Natural Product. 2016, 79, 5, 1308–1315.  W. S. Daniel Tan, Hong Yong Peh, Wupeng Liao, Chu Hui Pang, Tze Khee Chan, Suk Hiang Lau, Vincent T. Chow, and W. S. Fred Wong

https://pubs.acs.org/doi/10.1021/acs.jnatprod.5b01006

1. Andrographolide Restores Steroid Sensitivity To Block Lipopolysaccharide/IFN-γ–Induced IL-27 and Airway Hyperresponsiveness in Mice

J Immunol June 1, 2016, 196 (11) 4706-4712.  Wupeng Liao, W. S. Daniel Tan and W. S. Fred Wong

https://www.jimmunol.org/content/196/11/4706

1. Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis

Cell Death & Disease volume 10, Article number: 957 (2019).  Jian Gao, Shuang Peng, Xinni Shan, Guoliang Deng, Lihong Shen, Jian Sun, Chunhong Jiang, Xiaoling Yang, Zhigang Chang, Xinchen Sun, Fude Feng, Lingdong Kong, Yanhong Gu, Wenjie Guo, Qiang Xu & Yang Sun

https://www.nature.com/articles/s41419-019-2195-8

1. Restoration of HDAC2 and Nrf2 by Andrographolide Overcomes Corticosteroid Resistance in Chronic Obstructive Pulmonary Disease.

British Journal of Pharmacology. Apr 2020

Wupeng Liao,  Albert Y. H. Lim,  W. S. Daniel Tan,  John Abisheganaden,  W. S. Fred Wong

https://bpspubs.onlinelibrary.wiley.com/doi/epdf/10.1111/bph.15080

Andrographis Mechanism of Action Research

1. Andrographolide interferes with binding of nuclear factor-κB to DNA in HL-60-derived neutrophilic cells

Br J Pharmacol. 2005 Mar; 144(5): 680–686.  María A Hidalgo, Alex Romero, Jaime Figueroa, Patricia Cortés, Ilona I Concha, Juan L Hancke, and Rafael A Burgos

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576048/pdf/144-0706105a.pdf

1. Andrographolide Inhibits INF-g and IL-2 Cytokine Production and Protects against Cell Apoptosis. Planta Medica. 71 (5), 429-434 (2005).A. Burgos et al

https://pubmed.ncbi.nlm.nih.gov/15931581/

1. Andrographolide Reduces IL-2 Production in T-Cells by Interfering with NFAT and MAPK Activation

Eur. J. Pharmacol. 602(2-3), 413–421 (2009).  María D Carretta, Pablo Alarcón, Evelyn Jara, Loreto Solis, Juan L Hancke, Ilona I Concha, María A Hidalgo, Rafael A Burgos

https://www.sciencedirect.com/science/article/abs/pii/S0014299908011278?via%3Dihub

1. Is there a future for andrographolide to be an anti-inflammatory drug? Deciphering its major mechanisms of action

Biochem Pharmacol. 2017 Sep 1;139:71-81  W.S. Daniel, Tana Wupeng, Liaoa Shuo Zhoua, W.S. Fred Wong

https://www.sciencedirect.com/science/article/abs/pii/S0006295217301880?via%3Dihub

1. Multi-Targeting Andrographolide, a Novel NF-kB Inhibitor, as a Potential Therapeutic Agent for Stroke.

Int J Mol Sci. 2017 Aug; 18(8): 1638.  Chih-Hao Yang, Ting-Lin Yen, Chia-Yuan Hsu, Philip-Aloysius Thomas, Joen-Rong Sheu, and Thanasekaran Jayakumar

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578028/

1. Andrographolide, A Natural Antioxidant: An Update

Antioxidants 2019, 8, 571;  Eugenie Mussard, Annabelle Cesaro, Eric Lespessailles, Brigitte Legrain, Sabine Berteina-Raboin and Hechmi Toumi

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943416/pdf/antioxidants-08-00571.pdf

Andrographis In Vitro & In Vivo Bone & Joint Research

1. Andrographolide Induced Cell Cycle Arrest and Apoptosis in Human Rheumatoid Arthritis Fibroblast-Like Synoviocytes.

Cell Biol Toxicology. 2012 Feb;28(1):47-56J.  

Jie Yan, Yang Chen, Chao He, Zhen-zhen Yang, Cheng Lü, Xin-shan Chen https://link.springer.com/article/10.1007%2Fs10565-011-9204-8

1. Andrographolide suppresses RANKL-induced osteoclastogenesis in vitro and prevents inflammatory bone loss in vivo

British Journal of Pharmacology Sep 2013. 

Z J Zhai, H W Li, G W Liu, X H Qu, B Tian, W Yan, Z Lin T T Tang, A Qin and K R Dai

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969079/

1. Andrographolide Attenuates Skeletal Muscle Dystrophy In Mdx Mice And Increases Efficiency of Cell 3 Therapy by Reducing Fibrosis

Skeletal Muscle 4 (6), (2014).  D. Cabrera et al.,

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021597/pdf/2044-5040-4-6.pdf

1. Andrographolide Exerts Chondroprotective Activity in Equine Cartilage Explant and Suppresses Interleukin-1β-Induced MMP-2 Expression in Equine Chondrocyte Culture

International Scholarly Research Notices 1–8 (2014). S. Tangyuenyong, et al.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897368/

1. Andrographolide Inhibits Ovariectomy-Induced Bone Loss via the Suppression of RANKL Signaling Pathways

International Journal of Molecular Science 16 (11), 27470–27481 (2015). T. Wang et al. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661897/

1. Andrographolide Inhibits the Migration, Invasion and Matrix Metalloproteinase Expression Of Rheumatoid Arthritis Fibroblast-Like Synoviocytes via Inhibition of HIF-1α Signaling

Life Sci. 136, 67–72 (2015).  Cell Biol. Toxicol. 28 (1), 47–56 (2012).  L. Guo-feng et al., https://www.sciencedirect.com/science/article/abs/pii/S0024320515003434?via%3Dihub

Andrographis Anti-aging Research

1. The Antiaging Properties of Andrographis paniculata by Activation Epidermal Cell Stemness.

Molecules. 2015 Sep; 20(9): 17557–17569.  Jiyoung You, Kyung-Baeg Roh, Zidan Li, Guangrong Liu, Jian Tang, Seoungwoo Shin, Deokhoon Park and Eunsun Jung.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332002/pdf/molecules-20-17557.pdf

1. Andrographolide, a New Hope in the Prevention and Treatment of Metabolic Syndrome

Frontier in Pharmacology, 23 August 2017.   Muhammad T. Islam

https://www.frontiersin.org/articles/10.3389/fphar.2017.00571/full

Andrographis Liver Health Research

1. Review on Liver Inflammation and Anti-inflammatory Activity of Andrographis paniculata for Hepatoprotection

Phytother. Res. 28: 1589–1598 (2014)   Lee Suan Chua

https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.5193

1. A Diterpenoid, 14-Deoxy-11, 12-Didehydroandrographolide, in Andrographis paniculata Reduces Steatohepatitis and Liver Injury in Mice Fed a High-Fat and High-Cholesterol Diet

Nutrients 2020, 12(2), 523.  Yun-Ta Liu , Haw-Wen Chen, Chong-Kuei Lii,Jia-Hua Jhuang, Chin-Shiu Huang,Mei-Ling Li and Hsien-Tsung Yao

https://www.mdpi.com/2072-6643/12/2/523/htm

1. Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis

Nature Scientific Reports 7: 3491 2017. Daniel Cabrera et al

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471224/pdf/41598_2017_Article_3675.pdf