NHR Science Advance Immune Support Combo Pack is a comprehensive arsenal of immune-supportive powerful herbs, helping the body maintain a strong defense, and help supports seasonal immune health. Products that comprise in this combo packs were selected for their abilities to support the body’s overall immune response, encourage timely immune cell response, and help defend the body in the face of cold-weather challenges.  The clinically studied ingredients have been shown to provide the following benefits:

  • Promotes Healthy Immune & Inflammatory Response*
  • Supports Seasonal Immune Health*
  • Encourages Timely Immune Cell Response*
  • Enhances Antioxidant Defense and Helps Inhibit Oxidative Stress*
  • Provides comprehensive support for aging immune system*
  • Inhibits immune senescence by supporting healthy cortisol level and healthy ratio of naïve-to-memory T cells*


Immune 101

Your body’s immune system is your natural protection against harmful invaders.  The level 1 defense is your natural barriers like your skin that protects you from harmful invaders, and cilia (tiny hairs in your lungs) that brushes out unwelcome intruder so that your body can take them out. 

If level 1 fails and invaders slips through, level 2 innate immune defense kicks in.  The innate immunity comprises of a complex network of cells and proteins that defends the body against invaders.  When an invader gets in, your body’s cells and chemicals get on the scene fast – a lot like first responders in real life. They love to fight and they prevent the spread of invaders in the body.

These innate immune cells and proteins include:

  • Defensins send signals for help or fight invaders directly
  • Cytokines send signals for help
  • Natural killer cells destroy invaders
  • Scavenger cells (like neutrophils and macrophages) destroy invaders
  • And many other chemicals and cells

Level 3:  Your adaptive or acquired immunity is your stored immune memory of past occurrence and are trained to destroy agents quickly if invaders enter the body again.  Antibodies are part of that response and help your body respond to the same invader much faster if you encounter it again.  Some antibodies have a long-lasting effect and are called “memory” antibodies.

These adaptive immune cells include:

  • CD4+T Cell
  • CD8+ T Cell
  • B Cell

Your immune system fights infections using organs, cells and proteins that work together in a highly coordinated dance. Healthy eating, good nutrition, less stress, good sleeping habit and regular physical activity make your immune system stronger and can help you support your immune system.


Aging & Immune

Aging and other environmental stressors (due to excess inflammation, toxins, and stress) all contribute to a decline in our immune function. As you grow older, your immune system does not work as well, leaving us increasingly susceptible to health threats.   Your body may heal more slowly as there are fewer immune cells in the body to bring about healing.  The immune system's ability to detect and correct cell defects also declines.  In addition, immune cell diversity also declines, reducing our body’s immune defense.  This process is called immune senescence.

The following immune system changes may occur:

  1. Decline in Naïve T Cells.  Naïve T cells are inexperience T cells that can easily be activated to recognize and respond to new challenges.  There is a general decrease in naïve T cells after roughly age 70.   As a result, our immune system becomes slower to respond and this increases our risk of getting sick.
  2. Increasing Numbers of Senescent Memory T cells. Memory T cells are your stored immune memory of past occurrence that are trained to destroy invaders if they enter the body again.  Our body’s pool of protective memory T cells increase over time.  However, memory T cells from older persons are often senescent, meaning they lost their ability to proliferate and have become dysfunctional.
  3. Decreased in Functional Natural Killer (NK) Cell Activity. High NK cell activity is associated with longevity and healthy aging, while reduced NK cell function is linked to increased health imbalances.  NK cell function decreases with age, generating fewer immune-regulating cytokines.
  4. Overproduction of Cytokines: Immune senescence is associated with high levels of the inflammatory cytokine interleukin-6 (IL-6).  In the elderly, elevated IL-6 is associated with many health challenges. 

What to do to improve Immune health

  1. Exercise helps boost your immune system.  Regular moderate-intensity exercise can strengthen resistance to invaders and improve immune system function.  Several human studies have indicated that moderate exercise may combat immune senescence.
  2. Stress management. Chronic stress diminishes our immune function and dysregulate our innate and adaptive immune responses. Studies had shown cortisol (stress hormone) to contribute to immune senescence.  In fact, the ratio of cortisol to dehydroepiandrosterone (DHEA), may be an important determinant of immune senescence.
  3. Sleep deprivation is associated with elevated cortisol levels, as well as higher daytime levels of inflammatory cytokines including IL-1, IL-6, and tumor necrosis factor-alpha.  The adverse effects of poor sleep include functional changes in regulatory T cells and other cells of the adaptive immune system, as well as reduced numbers of NK cells and T and B cells.  Adequate sleep may help improve immune function.
  4. Calorie Restriction. The goal of caloric restriction is to reduce total caloric intake while maintaining optimal nutrition. Eat healthy foods primarily composed of low-calorie, nutrient-dense foods such as vegetables, fruits, legumes, nuts and seeds, and whole grains; limiting intake of animal products; and avoiding calorie-dense, nutrient-poor foods.  Calorie restriction in animals has been shown to prolong lifespan and delay aging, and to confer a more youthful T-cell profile.  Good nutrition keeps your immune system strong.
  5. DO NOT smoke. Smoking weakens your immune system.
  6. Limit your intake of alcohol. Ask your provider how much alcohol is safe for you. 

Botanicals to Support Immune health

Andrographis paniculata has traditionally been used in Indian and Chinese herbal medicine to support seasonal immune health.  There are currently 33 published research of randomized controlled trials (7175 patients) either using Andrographis as a monotherapy and as herbal mixture, showing Andrographis to be effective in supporting the body’s overall immune response to help defend the body in the face of cold-weather challenges.

ParActin® is a patented extract from Andrographis paniculata, standardized to 50% andrographolide. ParActin® works by inhibiting NF-kB -- key regulator of the human immune and inflammatory response system. When NF-kB is inhibited, pro-inflammatory cytokines and proteins such as COX2, prostaglandins, IL-6, IL-12, INF-γ TNF-α can be reduced.


ParActin® also increases the Nrf2-Keap1-ARE (Antioxidant Response Element) pathway, to augment the body’s natural antioxidant enzymes such as heme oxygenase-1, glutathione reductase, glutathione peroxidase, and superoxide dismutase, among others, to help reduce oxidative stress and promote healthy autophagy function. 

There are many published studies on the immune-support mechanisms of action of andrographolide: Andrographolide modulate the innate immune response by regulating both classical and alternative activation of macrophages, and regulate specific antibody production.  It inhibits agent’s protein synthesis and expression, inhibits it from entering inside the cell wall, inhibits the agent’s DNA replications; reduces the agent’s receptor signaling, & decreases ACE2 expression.

Eurycoma Longifolia

Eurycoma longifolia also known as Tongkat Ali (TA), comes from the lush rainforest of Southeast Asia, such as Malaysia, Vietnam, Java, and Thailand.   The roots of TA have traditionally been used as a tonic, energy enhancer, and aphrodisiac. TA is an adaptogen, it modulates the free testosterone/cortisol level, improve mood state, enhance energy and endurance, and help with recovery.

 LJ100® is a patented extract from Eurycoma longifolia, standardized to 40% glyco saponins and 22% Eurypeptides.  Cortisol is a stress hormone that promotes immunosenescence by inducing a shift from a CD4+ to CD8+ dominant pattern of immunity.  Several published human clinicals have confirmed that LJ100® reducing the cortisol stress hormone and elevate the free testosterone during endurance exercise as in volunteers with moderate stress.

In a study published in 2006, 30 men recruited from a 24-hour mountain biking event were given either 100mg of LJ100® or placebo.  The volunteers completed four 15-mile laps (total 60 miles) and provided eight saliva samples.  At the end of the study, cortisol levels were 32.3% lower in the LJ100® group compared to placebo, and free testosterone levels were 16.4% higher in the LJ100® group compared to placebo suggesting LJ100® apoptogenic ability to maintain low normal levels of cortisol and high normal levels of testosterone, improved anabolic state during intense endurance workouts.

In a 2013 randomized placebo-controlled study, 63 subjects (32 men, 32 women) with moderate stress were given 200mg of LJ100® or placebo for 4 weeks. LJ100® showed improved overall mood state: Tension (−11%), Anger (−12%), and Confusion (−15%).  Stress hormone profile (salivary cortisol and testosterone) was significantly improved by LJ100® supplementation, reduced cortisol exposure (−16%) and increased testosterone status (+37%).


 In a 2016 randomized placebo controlled study, 84 middle-aged men & women with low Scoring of Immunological Vigor (SIV) were given 200mg/day of LJ100® for 1 month. LJ100® promotes immunosenescence by significantly improved SIV score, immunological grade, and immunological age by 4 years. The number of total, naïve, CD4+ T cells, and natural killer cells were also significantly increased.


In another study with healthy male recreational athletes, supplementation with LJ100® significantly increased NK cells, supporting immune functions after endurance running in the heat.

In a randomized, double-blind placebo-controlled clinical trial of 312 economy class passengers travelling internationally, supplementation of elderberry supplement encouraged timely immune cell response and supports the body to maintain a strong defense during stressful intercontinental air travel. 


Elderberry is primarily found in Europe and North America.  Black Elderberries have long been used in traditional cultures to support immune function. Elderberry has an extensive history of being used during seasonal immune challenges. Regarded as an “Elder” plant in Native American Herbalism, Elderberry has been used collectively by many tribes as a tonic medicine and food to promote health and vitality.

In another randomized, double-blind, placebo-controlled study during the influenza season of 1999 – 2000 in Norway, 60 volunteers received 15 ml of elderberry or placebo syrup four times a day for 5 days. Supplementation of elderberry help support immune function during seasonal immune challenges.


What is in Advanced Immune Support Pack? 

Discover the research & science of the ingredients that can help support healthy immune and inflammatory response, support seasonal immune health, support aging immune health by supporting healthy cortisol level and healthy T cells.



  • Promotes Healthy Immune Response*
  • Supports Healthy Inflammatory Response*
  • Supports Nose, Throat, & Respiratory Health*
  • Supports Seasonal Immune Health*
  • Encourages Timely Immune Cell Response*
  • Enhances Antioxidant Defense and Helps Inhibit Oxidative Stress*


Tongkat Ali

  • Promotes Healthy Cortisol Levels*
  • Provides comprehensive support for aging immune system*
  • Inhibits immune senescence by supporting an already-healthy ratio of naïve-to-memory T cells*
  • Promotes youthful immune response by stimulating immune cell development & activity*
  • Encourages the body’s first line of defense by promoting natural killer (NK) cell response*



  • Comprehensive Immune Support*
  • Supports Nose, Throat, & Respiratory Health*
  • Helps Protect Against Seasonal Immune Challenges*
  • Provides Healthy Antioxidant Level*
  • Free Radical Scavenger*


    I am glad I found these products. I’ve noticed my energy level has increased, I sleep better, and my overall well-being seems to have gotten better as I've been taking it regularly. I highly recommend it. - Vicky Verified Purchase


    *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.