Research - Tongkat Ali

References

LJ100® Human Clinical Research Andropause, Men’s Sexual Health

  1.  LJ100® as a Potential Natural Energizer for Healthy Aging in Men.

First Asian Andrology 2002.  M.I.M. Tambi, S. Othman AND J.M. Saad.

  1. LJ100®, a Potent Adaptogen, Maintains Healthy Aging in Men

International Journal of Andrology (2005). Vol. 28(Suppl 1):25-44.  Asian Journal of Andrology, Oct 2006, 0154 (448).  The Aging Male (2007). F11-Pg 92.  Tambi, M.I. Kadir, A.B.

  1. LJ100® in Managing Idiopathic Male Infertility

Asian Journal of Andrology (2010) 12: 376–380.  Mohd Ismail Bin Mohd Tambi1, M. Kamarul Imran

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739276/

  1. LJ100® as Testosterone Booster for Managing Men with Late-onset Hypogonadism

First International Journal of Andrologia 2011.  M. I. B. M. Tambi, M. K. Imran & R. R. Henkel

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1439-0272.2011.01168.x

  1. Phytoandrogenic Properties of LJ100® as Natural Alternative to Testosterone Replacement Therapy

Andrologia. Jan 2014.  George A, Henkel R

https://onlinelibrary.wiley.com/doi/abs/10.1111/and.12214

  1. Effects of LJ100® on Sexual Performance & Well-being in Men with Reduced Sexual Potency

Published: Evidence-Based Complementary and Alternative Medicine, Volume 2014, Article ID: 179529

Udani J, Gruenwald J, Miller M, George A, Mufiza M, Abas A,

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914427/pdf/ECAM2014-179529.pdf 

  1. Randomized Clinical Trial on the Use of LJ100® for the Improvement of Quality of Life and Sexual Well-Being in Men

Evidence-Based Complementary and Alternative Medicine, Volume 2012.  Shaiful Bahari Ismail, Wan Mohd Zahiruddin W Mohammad, Annie George, Nik Hazlina Nik Hussain, Zatul Mufiza Musthapa Kamal, & Eckehard Liske

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518798/pdf/ECAM2012-429268.pdf

LJ100® Human Clinical Research Sport Nutrition

  1. The Ergogenic Effects of LJ100®

British Journal of Sports Medicine (2003). BASEM Abstract 37:465-466.  Hamzah, S and Yusuf, A.

https://pdfs.semanticscholar.org/f08d/579cb3ad8dd587c5784b2761a59dc7618722.pdf

  1. Effect of LJ100® on Anabolic Balance During Endurance Exercise

Journal of International Society of Sport Medicine 3 (1): S32 2006.  Talbott S, Talbott J, Negrete J, Jones M, Nichols M, and Roza J. 

  1. Effects of Strength Training and LJ100® Supplementation on Strength and Muscle Size in Middle-aged Women

4th Asia-Pacific Conference on Exercise and Sport Science & 8th International Sports Science Conference (2009).  Sarina, M.Y.

https://www.researchgate.net/publication/301258972_Enhancement_Effects_of_Tongkat_Ali_Eurycoma_longifolia_Supplementation_on_Performance_Functions_Following_Strength_Training_in_Middle-Aged_Women

  1. LJ100® as a Potential Herbal Supplement for Physically Active Male and Female Seniors

PHYTOTHERAPY RESEARCH (2013).  Ralf R. Henkel, Ruxiang Wang, Susan Bassett, Tao Chen, Na Liu, Ying Zhu, and Mohd Ismail Tambi

https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.5017

  1. Supplementation of Eurycoma longifolia Jack Extract for 6 Weeks Does Not Affect Urinary Testosterone: Epitestosterone Ratio, Liver and Renal Functions in Male Recreational Athletes

Int J Prev Med. 2014 Jun; 5(6): 728–733.  Chee Keong Chen, Wan Mohd Zahiruddin Wan Mohamad, Foong Kiew Ooi, Shaiful Bahari Ismail, Mohamad Rusli Abdullah, and Annie George

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085925/

  1. Effects of Eurycoma Longifolia Jack Supplementation Combined with Resistance Training on Isokinetic Muscular Strength and Power, Anaerobic Power, and Urinary Testosterone: Epitestosterone Ratio in Young Males

International Journal of Preventive Medicine.  2019; 10: 118.  Chee Keong Chen, Foong Kiew Ooi, Nurul Ain Abu Kasim, and Mohd Asnizam Asari

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639844/

LJ100® Human Clinical Research Cortisol, Mood, Immune

  1. Effect of LJ100® on Stress Hormones and Psychological Mood State in Moderately Stressed Subjects

Journal of the International Society of Sports Nutrition 2013, 10:28.  Shawn M Talbott, Julie A Talbott, Annie George, Mike Pugh

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669033/

  1. Immunomodulation in Middle-Aged Humans Via the Ingestion of LJ100®

Phytotherapy Research 2016.  Annie George, Naoko Suzuki, Azreena Binti Abas, Kiminori Mohri

https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.5571         

  1. Efficacy and safety of Eurycoma longifolia (Physta®) water extract plus multivitamins on quality of life, mood and stress: a randomized placebo-controlled and parallel study

Food Nutr Res. 2018; 62: 10.29219/fnr.v62.1374.  Annie George, Jay Udani, Nurhayati Zainal Abidin, and Ashril Yusof

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294837/

In Vitro & In Vivo Published Research Sexual Health

  1. Phenolic-rich extracts of Eurycoma longifolia and Cylicodiscus gabunensis inhibit enzymes responsible for the development of erectile dysfunction and are antioxidants

J Basic Clin Physiol Pharmacol. 2018 Nov 27;29(6):689-696.  Ganiyu Oboh, Adeniyi A Adebayo, Ayokunle O Ademosun

https://pubmed.ncbi.nlm.nih.gov/29777610/

  1. Brain Cortical and Hippocampal Dopamine: A New Mechanistic Approach for Eurycoma longifolia Well-Known Aphrodisiac Activity and Its Chemical Characterization

Evidence-Based Complementary and Alternative Medicine Volume 2019, Article ID 7543460.  Shahira M. Ezzat, Marwa I. Ezzat, Mona M. Okba, Salah M. Hassan, Amgad I. Alkorashy, Mennatallah M. Karar, Sherif H. Ahmed, and Shanaz O. Mohamed

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582863/pdf/ECAM2019-7543460.pdf

  1. Rho-Kinase II Inhibitory Potential of Eurycoma longifolia New Isolate for the Management of Erectile Dysfunction

Evid Based Complement Alternat Med. 2019: 4341592. Shahira M. Ezzat, Mona M. Okba, Marwa I. Ezzat, Nora M. Aborehab, and Shanaz O. Mohamed

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541974/

In Vitro & In Vivo Published Research Weight Loss

  1. Antiadipogenic effects of a standardized quassinoids-enriched fraction and eurycomanone from Eurycoma longifolia

Phytothery Research. 2018 Jul;32(7):1332-1345.  D Balan, Kit-Lam Chan, D Murugan, Sazaly A Bakar, Pooi-Fong Wong

https://onlinelibrary.wiley.com/doi/epdf/10.1002/ptr.6065

  1. Selection of Thai Medicinal Plants with Anti-Obesigenic Potential via in vitro method

Pharmaceuticals 2020, 13, 56;  Wijitrapha Ruangaram 1 and Eisuke Kato

https://www.mdpi.com/1424-8247/13/4/56

In Vitro & In Vivo Published Research Bone Health

  1. Combined Effects of Eurycoma longifolia and Testosterone on Androgen-Deficient Osteoporosis in a Male Rat Model

Evid Based Complement Alternat Med. 2012; 2012: 872406. Halimatun S.A Razak,  Ahmad N Shuid, and Isa N Mohamed

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424595/

  1. Effects of Eurycoma longifolia on Testosterone Level and Bone Structure in an Aged Orchidectomised Rat Model

Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 818072.  Abdul Shukor Tajul Ariff, Ima Nirwana Soelaiman, J. Pramanik, and Ahmad Nazrun Shuid

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433727/pdf/ECAM2012-818072.pdf

  1. Eurycoma longifolia as a potential alternative to testosterone for the treatment of osteoporosis: Exploring time-mannered proliferative, differentiative and morphogenic modulation in osteoblasts

J Ethnopharmacol . 2017 Jan 4;195:143-158.  Hnin Ei Thu, Isa Naina Mohamed, Zahid Hussain, Ahmad Nazrun Shuid

https://pubmed.ncbi.nlm.nih.gov/27818256/

  1. The Effects of Quassinoid-Rich Eurycoma longifolia Extract on Bone Turnover and Histomorphometry Indices in the Androgen-Deficient Osteoporosis Rat Model

Nutrients 2018, 10, 799;  Putri Ayu Jayusman , Isa Naina Mohamed , Ekram Alias, Norazlina Mohamed and Ahmad Nazrun Shuid

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073572/

  1. An Evidence-Based Review: The Effects of Malaysian Traditional Herbs on Osteoporotic Rat Models

Malays J Med Sci. 2018 Jul; 25(4): 6–30.  Nur Adlina Mohammad, Norfarah Izzaty Razaly, Mohd Dzulkhairi Mohd Rani, Muhammad Shamsir Mohd Aris, Nadia Mohd Effendy

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422536/pdf/02mjms25042018_ra1.pdf

  1. Exploring molecular mechanism of bone-forming capacity of Eurycoma longifolia: Evidence of enhanced expression of bone-related biomarkers

Journal of Ayurveda and Integrative Medicine 9 (2018) 272e280.  Hnin Ei Thu, Isa Naina Mohamed, Zahid Hussain, Ahmad Nazrun Shuid

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314246/pdf/main.pdf

  1. Eurycoma longifolia, a promising suppressor of RANKL-induced differentiation and activation of osteoclasts: An in vitro mechanistic evaluation

Journal of Ayurveda and Integrative Medicine 10 (2019) 102e110.  Hnin Ei Thu, Zahid Hussain, Isa Naina Mohamed, Ahmad Nazrun Shuid

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598823/pdf/main.pdf

  1. Effect of herbal extract Eurycoma longifolia (Physta®) on female reproductive hormones and bone biochemical markers: an ovariectomised rat model study

BMC Complementary Medicine and Therapies (2020) 20:31.  Sasikala M. Chinnappan, Annie George, Godavarthi Ashok and Yogendra Kumar Choudhary

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076899/pdf/12906_2020_Article_2814.pdf

In Vitro & In Vivo Published Research Inflammation

  1. Eurycomanone and Eurycomanol from Eurycoma longifolia Jack as Regulators of Signaling Pathways Involved in Proliferation, Cell Death and Inflammation

Molecules 2014, 19, 14649-14666.  Shéhérazade Hajjouli, Sébastien Chateauvieux, Marie-Hélène Teiten, Barbora Orlikova, Marc Schumacher, Mario Dicato, Chee-Yan Choo and Marc Diederich

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270735/pdf/molecules-19-14649.pdf

  1. NF-κB Inhibitors from Eurycoma longifolia

J Nat Prod. 2014 Mar 28; 77(3): 483–488.  Thi Van Anh Tran, Clemens Malainer, Stefan Schwaiger, Atanas G. Atanasov, Elke H. Heiss, Verena M. Dirsch, and Hermann Stuppner

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971761/pdf/np400701k.pdf

  1. Anti-inflammatory and analgesic effects of Eurycoma longifolia extracts

Arch Pharm Res. 2016 Mar;39(3):421-8.  Young Min Han, Sang-Uk Woo, Min Sun Choi, Yu Na Park, Seung Hyun Kim, Hyungshin Yim, Hye Hyun Yoo

https://link.springer.com/article/10.1007/s12272-016-0711-2

  1. Eurycomalactone Inhibits Expression of Endothelial Adhesion Molecules at a Post-Transcriptional Level

Journal of Natural Products. 2017, 80, 3186−3193.  Clemens Malainer, Daniel Schachner, Enrico Sangiovanni, Atanas G. Atanasov, Stefan Schwaiger,

Hermann Stuppner, Elke H. Heiss, and Verena M. Dirsch

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744186/pdf/np7b00503.pdf

 

  1. Nephroprotective Effect of Herbal Extract Eurycoma longifolia on Paracetamol-Induced Nephrotoxicity in Rats

Evidence-Based Complementary and Alternative Medicine. Volume 2019, Article ID 4916519.  Sasikala M. Chinnappan, Annie George, Praveen Thaggikuppe, YogendraKumar Choudhary, Vandana K. Choudhary, Yesha Ramani, and Rashmi Dewangan

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535855/pdf/ECAM2019-4916519.pdf