NHR Science Advanced Immune Support Pack is a comprehensive arsenal of immune-supportive powerful herbs, helping the body maintain a strong defense, and help supports seasonal immune health. The 3 NHR Science products that comprise this Immune Support Pack were selected for their abilities to support the body’s overall immune response, encourage timely immune cell response, and help defend the body in the face of cold-weather challenges.
60-Day Advanced Immune Support Pack Contains 2 Bottles Each of:
• ParActin® Immune
• Adapticort®
• Elderberry
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
(Please note that this bundle cannot ship to Canada)
STAY HEALTHY: OPTIMIZE HEALTHY IMMUNE RESPONSE, HELP SUPPORT HEALTHY RESPIRATORY FUNCTION*
NHR Science Advance Immune Support Combo Pack is a comprehensive arsenal of immune-supportive powerful herbs, helping the body maintain a strong defense, and help supports seasonal immune health. Products that comprise in this combo packs were selected for their abilities to support the body’s overall immune response, encourage timely immune cell response, and help defend the body in the face of cold-weather challenges. The clinically studied ingredients have been shown to provide the following benefits:
- Promotes Healthy Immune & Inflammatory Response*
- Supports Seasonal Immune Health*
- Encourages Timely Immune Cell Response*
- Enhances Antioxidant Defense and Helps Inhibit Oxidative Stress*
- Provides comprehensive support for aging immune system*
- Inhibits immune senescence by supporting healthy cortisol level and healthy ratio of naïve-to-memory T cells*
What is in Advanced Immune Support Pack?
Discover the research & science of the ingredients that can help support healthy immune and inflammatory response, support seasonal immune health, support aging immune health by supporting healthy cortisol level and healthy T cells.
- Promotes Healthy Immune Response*
- Supports Healthy Inflammatory Response*
- Supports Nose, Throat, & Respiratory Health*
- Supports Seasonal Immune Health*
- Encourages Timely Immune Cell Response*
- Enhances Antioxidant Defense and Helps Inhibit Oxidative Stress*
Adapticort - Wild Harvested Eurycoma Longifolia 100:1 Extract
- Promotes Healthy Cortisol Levels*
- Provides comprehensive support for aging immune system*
- Inhibits immune senescence by supporting an already-healthy ratio of naïve-to-memory T cells*
- Promotes youthful immune response by stimulating immune cell development & activity*
- Encourages the body’s first line of defense by promoting natural killer (NK) cell response*
ElderberryCare Organic Elderberry 12:1 Extract
- Comprehensive Immune Support*
- Supports Nose, Throat, & Respiratory Health*
- Helps Protect Against Seasonal Immune Challenges*
- Provides Healthy Antioxidant Level*
- Free Radical Scavenger*
Immune 101
Your body’s immune system is your natural protection against harmful invaders. The Level 1 defense is your natural barriers like your skin that protects you from harmful invaders, and cilia (tiny hairs in your lungs) that brushes out unwelcome intruder so that your body can take them out.
If Level 1 fails and invaders slips through, Level 2 innate immune defense kicks in. The innate immunity comprises of a complex network of cells and proteins that defends the body against invaders. When an invader gets in, your body’s cells and chemicals get on the scene fast – a lot like first responders in real life. They love to fight and they prevent the spread of invaders in the body.
Level 2 innate immune cells and proteins include:
- Defensins send signals for help or fight invaders directly
- Cytokines send signals for help
- Natural killer cells destroy invaders
- Scavenger cells (like neutrophils and macrophages) destroy invaders
- And many other chemicals and cells
Level 3 Adaptive or Acquired immunity
CD4+T Cell, CD8+ T Cell, & B Cell are your stored immune memory of past occurrence and are trained to destroy agents quickly if invaders enters the body again. Antibodies are part of that response and help your body respond to the same invader much faster if you encounter it again. Some antibodies have a long-lasting effects and are called “memory” antibodies.
Your immune system fights infections using organs, cells and proteins that work together in a highly coordinated dance. Healthy eating, good nutrition, less stress, good sleeping habit and regular physical activity make your immune system stronger and can help you support your immune system.
Aging & Immune
Aging and other environmental stressors (due to excess inflammation, toxins, and stress) all contribute to a decline in our immune function. As you grow older, your immune system does not work as well, leaving us increasingly susceptible to health threats. Your body may heal more slowly as there are fewer immune cells in the body to bring about healing. The immune system's ability to detect and correct cell defects also declines. In addition, immune cell diversity also declines, reducing our body’s immune defense. This process is called immune senescence.
The following immune system changes may occur:
- Decline in Naïve T Cells. Naïve T cells are inexperience T cells that can easily be activated to recognize and respond to new challenges. There is a general decrease in naïve T cells after roughly age 70. As a result, our immune system becomes slower to respond and this increases our risk of getting sick.
- Increasing Numbers of Senescent Memory T cells. Memory T cells are your stored immune memory of past occurrence that are trained to destroy invaders if they enter the body again. Our body’s pool of protective memory T cells increase over time. However, memory T cells from older persons are often senescent, meaning they lost their ability to proliferate and have become dysfunctional.
- Decreased in Functional Natural Killer (NK) Cell Activity. High NK cell activity is associated with longevity and healthy aging, while reduced NK cell function is linked to increased health imbalances. NK cell function decreases with age, generating fewer immune-regulating cytokines.
- Overproduction of Cytokines: Immune senescence is associated with high levels of the inflammatory cytokine interleukin-6 (IL-6). In the elderly, elevated IL-6 is associated with many health challenges.
What to Do to Improve Immune Health
- Exercise helps boost your immune system. Regular moderate-intensity exercise can strengthen resistance to invaders and improve immune system function. Several human studies have indicated that moderate exercise may combat immune senescence.
- Stress management. Chronic stress diminishes our immune function and dysregulate our innate and adaptive immune responses. Studies had shown cortisol (stress hormone) to contribute to immune senescence. In fact, the ratio of cortisol to dehydroepiandrosterone (DHEA), may be an important determinant of immune senescence.
- Sleep deprivation is associated with elevated cortisol levels, as well as higher daytime levels of inflammatory cytokines including IL-1, IL-6, and tumor necrosis factor-alpha. The adverse effects of poor sleep include functional changes in regulatory T cells and other cells of the adaptive immune system, as well as reduced numbers of NK cells and T and B cells. Adequate sleep may help improve immune function.
- Calorie Restriction. The goal of caloric restriction is to reduce total caloric intake while maintaining optimal nutrition. Eat healthy foods primarily composed of low-calorie, nutrient-dense foods such as vegetables, fruits, legumes, nuts and seeds, and whole grains; limiting intake of animal products; and avoiding calorie-dense, nutrient-poor foods. Calorie restriction in animals has been shown to prolong lifespan and delay aging, and to confer a more youthful T-cell profile. Good nutrition keeps your immune system strong.
- DO NOT smoke. Smoking weakens your immune system.
- Limit your intake of alcohol. Ask your provider how much alcohol is safe for you.
- Botanicals such as Andrographis, Eurycoma longifolia, and Elderberry all have studies that can help support your immune health.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Elderberry is primarily found in Europe and North America. Black Elderberries have long been used in traditional cultures to support immune function. Elderberry has an extensive history of being used during seasonal immune challenges. Regarded as an “Elder” plant in Native American Herbalism, Elderberry has been used collectively by many tribes as a tonic medicine and food to promote health and vitality.
In a randomized, double-blind placebo-controlled chinical trial with 63 subjects with moderate stress, 200mg of Adapticort daily for 4 weeks were able to improve overall mood state, and improved cortisol – 16%
In a 2016 radomized placebo controlled study, 84 middle-aged individual with low Scoring of Immunological Vigor (SIV) who were given 200mg/day of Adapticort for 1 month see significant improvement in SIV score, immunological Grade. Adapticort promotes youthful immune response by stimulating immune cell developement & activity, and the subject immunological age were improved by 4 years
Andrographis Paniculata has traditionally been used in Indian and Chinese herbal medicine to support seasonal immune health. There are currently 33 published research of randomized controlled trials (7175 patients) either using Andrographis as a monotherapy and as herbal mixture, showing Andrographis to be effective in supporting the body’s overall immune response to help defend the body in the face of cold-weather challenges.
Read More
Adapticort® Human Clinical Research Cortisol, Mood, Immune
- Effect of Adapticort® on Stress Hormones and Psychological Mood State in Moderately Stressed Subjects
Journal of the International Society of Sports Nutrition 2013, 10:28. Shawn M Talbott, Julie A Talbott, Annie George, Mike Pugh
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669033/
- Immunomodulation in Middle-Aged Humans Via the Ingestion of Adapticort®
Phytotherapy Research 2016. Annie George, Naoko Suzuki, Azreena Binti Abas, Kiminori Mohri
https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.5571
- Efficacy and safety of Eurycoma longifolia (Adapticort®) water extract plus multivitamins on quality of life, mood and stress: a randomized placebo-controlled and parallel study
Food Nutr Res. 2018; 62: 10.29219/fnr.v62.1374. Annie George, Jay Udani, Nurhayati Zainal Abidin, and Ashril Yusof
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294837/
Andrographis Immune Health Research
- A Double Blind Study with a New Monodrug: Kan Jang Decrease of Symptoms and Enhancement of Resistance to Common Colds.
Phototherapy Research 9: 559- 562, 1995. JL. Hancke et al.
https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.2650090804
- Prevention of common colds with Andrographis paniculata dried extract: A Pilot double blind trial
Phytomed. 4 (2), 101-104 (1997). D.D. Cáceres et al.
https://www.sciencedirect.com/science/article/abs/pii/S0944711397800517?via%3Dihub
- Use of visual analogue scale measurements (VAS) to asses the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomized double blind-placebo study
Phytomedicine Volume 6, Issue 4, October 1999, Pages 217-223. D.D.Cáceres, J.L.Hancke, R.A.Burgos, F.Sandberg, G.K.Wikman
https://www.sciencedirect.com/science/article/abs/pii/S0944711399800129?via%3Dihub
- Andrographolide As a Potential Inhibitor of SARS-CoV-2 Main Protease: An In Silico Approach
Journal of Biomolecular Structure and Dynamics, Apr 2020. Sukanth Kumar Enmozhi, Kavitha Raja, Irudhayasamy Sebastine, Tiruchirappalli, & Jerrine Joseph
https://www.tandfonline.com/doi/full/10.1080/07391102.2020.1760136
- Andrographis paniculata (Chuān Xīn LiaÂn) for symptomatic relief of acute respiratory tract infections in adults and children: A systematic review and meta-analysis
PLoS One. 2018; 13(11). Xiao-Yang Hu, Ruo-Han Wu, Martin Logue, Clara Blondel, Lily Yuen Wan Lai, Beth Stuart, Andrew Flower, Yu-Tong Fei, Michael Moore, Jonathan Shepherd, Jian-Ping Liu, and George Lewith
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235384/
- Immunomodulatory activity of andrographolide on macrophage activation and specific antibody response.
Acta Pharmacol Sin. 2010 Feb; 31(2): 191–201. Wei Wang, Jing Wang, Sheng-fu Dong, Chun-hong Liu, Paola Italiani, Shu-hui Sun, Jing Xu, Diana Boraschi, Shi-ping Ma, and Di Qu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002847/
Andrographis Anti-Viral Research
- Activity of Andrographolide and Its Derivatives against Influenza Virus in Vivo and in Vitro
Biological and Pharmaceutical. Volume 32 (2009) Issue 8
Jian-Xin Chen, Hui-Jun Xue, Wen-Cai Ye, Bing-Hu Fang, Ya-Hong Liu, Shao-Hua Yuan, Pei Yu, Yu-Qiang Wang
https://www.jstage.jst.go.jp/article/bpb/32/8/32_8_1385/_article
- A Phase I Trial of Andrographolide in HIV Positive Patients and Normal Volunteers
Phytotherapy Research. Volume14, Issue5 August 2000
Pages 333-338. Carlo Calabrese Sheryl H. Berman John G. Babish Xinfang Ma Lynne Shinto Melissa Dorr Kameron Wells Cynthia A. Wenner Leanna J. Standish
https://onlinelibrary.wiley.com/doi/abs/10.1002/1099-1573(200008)14:5%3C333::AID-PTR584%3E3.0.CO;2-D
- Activity of andrographolide against chikungunya virus infection
Scientific Report. 2015; 5: 14179. Phitchayapak Wintachai, Parveen Kaur, Regina Ching Hua Lee, Suwipa Ramphan, Atichat Kuadkitkan, Nitwara Wikan, Sukathida Ubol, Sittiruk Roytrakul, Justin Jang Hann Chu, and Duncan R. Smith
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585663/
- Broad-spectrum antiviral properties of andrographolide
Archives of Virology 162(3) · November 2016. Swati Gupta, K. P. Mishra.
- Analyzing the interaction of a herbal compound Andrographolide from Andrographis paniculata as a folklore against swine flu (H1N1)
Asian Pac J Trop Dis. 2014 Sep; 4: S624–S630. Chandrabhan Seniya, Shilpi Shrivastava, Sanjay Kumar Singh, and Ghulam Jilani Khan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129870/
- Antiviral and Immunostimulant Activities of Andrographis paniculata
HAYATI Journal of Biosciences 22(2) · April 2015. Churiyah, Elrade Rofaani, Olivia Bunga Pongtuluran
- Possible inhibitors of ACE2, the receptor of 2019-nCoV
Pharmacology & Toxicology February 2020. Qinghua Cui, Chuanbo Huang, Xiangwen Ji, Wanlu Zhang, Fenghong Zhang, Liang Wang
https://www.preprints.org/manuscript/202002.0047/v1
- Computational Investigation on Andrographis paniculata Phytochemicals to Evaluate Their Potency Against SARS-CoV-2 in Comparison to Known Antiviral Compounds in Drug Trials.
JOURNAL OF BIOMOLECULAR STRUCTURE AND DYNAMICS May 2020.
Natarajan Arul Murugan, Chitra Jeyaraj Pandian and Jeyaraman Jeyakanthan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309306/pdf/TBSD_A_1777901.pdf
- Crosstalk Between Endoplasmic Reticulum Stress and Anti-Viral Activities: A Novel Therapeutic Target for COVID-19.
Life Science 2020 Aug 15; 255: 117842.
Aditi Banerjee, Steven J. Czinn, Russel J. Reiter, and Thomas G. Blanchard
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245231/
Andrographis Lung Health Research
- Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity
British Journal of Pharmacology. Volume168, Issue7 April 2013 Pages 1707-1718.
SP Guan, W Tee, DSW Ng, TK Chan, HY Peh, WE Ho, C Cheng, JC Mak, WSF Wong
https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.12054
- Andrographolide Protects against LPS-Induced Acute Lung Injury by Inactivation of NF-kB
PLoS One. 2013; 8(2). Tao Zhu, Dao-xin Wang, Wei Zhang, Xiu-qing Liao, Xian Guan, Hong Bo, Jia-yang Sun, Ni-wen Huang, Jing He, Yun-kun Zhang, Jing Tong, and Chang-yi Li
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578846/
- Cigarette Smoke-Induced Lung Disease Predisposes to More Severe Infection with Nontypeable Haemophilus influenzae: Protective Effects of Andrographolide
Journal of Natural Product. 2016, 79, 5, 1308–1315. W. S. Daniel Tan, Hong Yong Peh, Wupeng Liao, Chu Hui Pang, Tze Khee Chan, Suk Hiang Lau, Vincent T. Chow, and W. S. Fred Wong
https://pubs.acs.org/doi/10.1021/acs.jnatprod.5b01006
- Andrographolide Restores Steroid Sensitivity To Block Lipopolysaccharide/IFN-γ–Induced IL-27 and Airway Hyperresponsiveness in Mice
J Immunol June 1, 2016, 196 (11) 4706-4712. Wupeng Liao, W. S. Daniel Tan and W. S. Fred Wong
https://www.jimmunol.org/content/196/11/4706
- Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis
Cell Death & Disease volume 10, Article number: 957 (2019). Jian Gao, Shuang Peng, Xinni Shan, Guoliang Deng, Lihong Shen, Jian Sun, Chunhong Jiang, Xiaoling Yang, Zhigang Chang, Xinchen Sun, Fude Feng, Lingdong Kong, Yanhong Gu, Wenjie Guo, Qiang Xu & Yang Sun
https://www.nature.com/articles/s41419-019-2195-8
- Restoration of HDAC2 and Nrf2 by Andrographolide Overcomes Corticosteroid Resistance in Chronic Obstructive Pulmonary Disease.
British Journal of Pharmacology. Apr 2020
Wupeng Liao, Albert Y. H. Lim, W. S. Daniel Tan, John Abisheganaden, W. S. Fred Wong
https://bpspubs.onlinelibrary.wiley.com/doi/epdf/10.1111/bph.15080
Elderberry Research Links:
- Inhibition of Several Strains of Influenza Virus in Vitro and Reduction of Symptoms by an Elderberry Extract {Sambucus nigra L.) during an Outbreak of Influenza B Panama.
Journal of Alternative Complementary Medecine . Winter 1995;1(4):361-9.
Z Zakay-Rones, N Varsano, M Zlotnik, O Manor, L Regev, M Schlesinger, M Mumcuoglu
https://www.liebertpub.com/doi/abs/10.1089/acm.1995.1.361
- Randomized Study of the Efficacy and Safety of Oral Elderberry Extract in
the Treatment of Influenza A and B Virus Infections
Journal of International Medical Research. Mar-Apr 2004;32(2):132-40.
Z Zakay-Rones, E Thom, T Wollan, J Wadstein
https://journals.sagepub.com/doi/abs/10.1177/147323000403200205
- Elderberry Supplementation Reduces Cold Duration and Symptoms in Air-Travellers: A Randomized, Double-Blind Placebo-Controlled Clinical Trial
Nutrients . 2016 Mar 24;8(4):182. Evelin Tiralongo, Shirley S. Wee, and Rodney A. Lea
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848651/pdf/nutrients-08-00182.pdf
- Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical
Trials
Complementary Therapies in Medicine Volume 42, February 2019, Pages 361-365
Jessie Hawkins, Colby Baker, Lindsey Cherry, Elizabeth Dunne
https://www.sciencedirect.com/science/article/abs/pii/S0965229918310240?via%3Dihub
- A Systematic Review on the Sambuci fructus Effect and Efficacy Profiles.
Phytotherapy Research. 2010 Jan;24(1):1-8. J E Vlachojannis, M Cameron, S Chrubasik
https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.2729
- Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses
BMC Complementary and Alternative Medicine 2011, 11:16. Christian Krawitz, Mobarak Abu Mraheil, Michael Stein, Can Imirzalioglu, Eugen Domann, Stephan Pleschka, Torsten Hain
https://bmccomplementmedtherapies.biomedcentral.com/track/pdf/10.1186/1472-6882-11-16
- Sambucus nigra extracts inhibit infectious bronchitis virus at an early point during replication
BMC Veterinary Research 2014, 10:24. Christie Chen, David M Zuckerman, Susanna Brantley, Michka Sharpe, Kevin Childress, Egbert Hoiczyk, and Amanda R Pendleton
https://bmcvetres.biomedcentral.com/track/pdf/10.1186/1746-6148-10-24
- Interfering With Lipid Raft Association: A Mechanism to Control Influenza Virus Infection By Sambucus Nigra
Iran J Pharm Res. 2017 Summer; 16(3): 1147–1154.
Shahla Shahsavandi, Mohammad Majid Ebrahimi, and Ameneh Hasaninejad Farahani
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610768/pdf/ijpr-16-1147.pdf
- Plant-made virus-like particles bearing influenza hemagglutinin (HA) recapitulate early interactions of native influenza virions with human monocytes/macrophages
Vaccine Volume 35, Issue 35, Part B, 16 August 2017, Pages 4629-4636.
Alexander I. Makarkov, Sabrina Chierzi, Stéphane Pillet, Keith K. Murai, Nathalie Landry,Brian J. Ward
https://www.sciencedirect.com/science/article/pii/S0264410X17309088?via%3Dihub