NHR Science

ParActin® Joint - For Joint & Muscle Health

$34.95
  • ParActin® Joint - For Joint & Muscle Health
ParActin® Joint - For Joint & Muscle Health ParActin® Joint - For Joint & Muscle Health ParActin® Joint - For Joint & Muscle Health ParActin® Joint - For Joint & Muscle Health ParActin® Joint - For Joint & Muscle Health

NHR Science

ParActin® Joint - For Joint & Muscle Health

$34.95


ParActin® Joint delivers compounds that help inhibits NF kappa B (the master switch of Inflammation), thereby naturally reduces proinflammatory cytokines and proteins to powerfully support joint health, nurture healthy joint cartilage, and support muscle health*.
  • Inhibits Inflammation to Support Healthy Joint, Cartilage, Bone & Muscle Health*
  • Inhibits Minor Pain & Discomfort Associated with Over Exertion*
  • Supports Healthy, Comfortable Freedom of Movement*
  • Shows Improved Joint Comfort Within 7 Days!*
  • Activates Nrf2-KEAP1-ARE Pathway*
  • Inhibits NF-kB (the Master Inflammation Switch)*
  • Reduces Pro-inflammatory Cytokines*
  • Inhibits Inflammation to Support Joint & Cartilage Health* 

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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ParActin® Joint - The Master Switch of Inflammation

ParActin® Joint delivers compounds that help inhibits NF kappa B (the master switch of Inflammation), thereby naturally reduces proinflammatory cytokines and proteins to powerfully support joint health, nurture healthy joint cartilage, and support muscle health*.

ParActin® Joint is more than just a joint supplement; it's a comprehensive solution designed to address the root causes of joint discomfort. By containing compounds that inhibit NF kappa B, known as the master switch of inflammation, it helps to naturally reduce proinflammatory cytokines and proteins, resulting in powerful support for joint health. In addition to promoting healthy joints and cartilage, ParActin® Joint extends its benefits to support overall muscle health, providing a holistic approach to your well-being.

ParActin® is suitable for dietary supplements that support the following condition-specific areas:

  • Joint Health
  • Healthy Bones
  • Healthy Cartilage
  • Sports Recovery/Muscle Function
  • Healthy Inflammatory Response
  • Overall Immune Function

Based on two human studies with ParActin® Joint,  subjects rated their joint health & physical function, improved within 7 days, and continued to improve throughout the duration of the studies*. 

Clinically Proven Health Benefits 

 

ParActin® is a safe, unique, standardized, patented, rigorously science-proven, proprietary nutraceutical. The anti-inflammatory benefits of ParActin® come from the standardized herbal extract, Andrographis paniculata which is sustainably harvested in India, China and Southeastern Asia.

“The scientific community is now recognizing decades of our research and development showing that ParActin® with its andrographolides have great potential to be the next new class of anti-inflammatory agents”.

Annie Eng, Founder & CEO

 

Staying Active is Important to Your Health and Longevity 

Maintaining an active lifestyle is paramount for your overall health and can significantly contribute to a longer and more fulfilling life. Regular physical activity not only keeps your body in good shape but also promotes mental well-being, helping you achieve a healthier, happier, and more vibrant existence.

Grab a bottle - or more - to harness the incredible power of Andrographis paniculata to help improve joint comfort in just 7 days, so you can keep doing all your favorite activities.*

Take ParActin® Joint as a drug-free way to help improve joint comfort in just 7 days, so you can keep doing all your favorite activities.*

ParActin® is a registered trademark of HP Ingredients Corporation.

For more research info on ParActin, go to www.paractin.com.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

 

NHR Science ParActin® Joint Andrographis paniculata Extract

Origins & Traditional Use
Andrographis paniculata, an annual herbaceous plant in the family Acanthaceae, is one of the most commonly used medicinal plants

in the traditional systems of Traditional Chinese and Ayurvedic medicines. It is widely cultivated in India, China, and Southeastern Asia.

It is known as the “king of bitters” due to its bitter flavor profile. Andrographolide, an active ingredient in Andrographis, has been shown to be responsible for the herb’s inflammatory modulating actions.

ParActin® is a patented extract of Andrographis paniculata, standardized to Andrographolide, 14-deoxyandrographolide, and Neoandrographolide. (US Patent No: 8,084,495 B2)

 

 

SUGGESTED USE: Take 300mg per day, which may be taken as 150mg twice daily, or as directed by your qualified healthcare professional.

OTHER INGREDIENTS: Vegetarian capsules (Hydroxypropyl Methylcellulose), Non-GMO Rice Flour.

NO artificial colors, flavors or preservatives. NO wheat, gluten, soy, dairy, egg, corn, yeast, fish/shellfish, peanuts or tree nuts. Non-GMO

 

ParActin® Andrographis Human Clinical Trials

  1. Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial

Clinical Rheumatology volume 28, pages931–946(2009)  R. A. Burgos, J. L. Hancke, J. C. Bertoglio, V.

Aguirre, S. Arriagada, M. Calvo & D. D. Cáceres

https://link.springer.com/article/10.1007/s10067-009-1180-5

  1. Andrographolide a New Potential Drug for the Long Term Treatment of Rheumatoid Arthritis Disease

Innovative Rheumatology Jan 2013.    

María A. Hidalgo, Juan L. Hancke, Juan C. Bertoglio and Rafael A. Burgos

https://www.intechopen.com/books/innovative-rheumatology/andrographolide-a-new-potential-drug-for-the-long-term-treatment-of-rheumatoid-arthritis-disease

  1. Andrographis paniculata decreases fatigue in patients with relapsing-remitting multiple sclerosis: a 12-month double-blind placebo-controlled pilot study

BMC Neurology volume 16, Article number: 77 (2016).  J. C. Bertoglio, M. Baumgartner, R. Palma, E. Ciampi, C. Carcamo, D. D. Cáceres, G. Acosta-Jamett, J. L. Hancke & R. A. Burgos

https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-016-0595-2

  1. A double‐blind, randomized, placebo‐controlled study to assess the efficacy of Andrographis paniculata standardized extract (ParActin®) on pain reduction in subjects with knee osteoarthritis

Phytotherapy Research.  Volume33, Issue5 May 2019 Pages 1469-1479. 

Juan L. Hancke  Shalini Srivastav  Dante D. Cáceres  Rafael A. Burgos

https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.6339

  1. Efficacy of Andrographolide in Not Active Progressive Multiple Sclerosis: A Prospective Exploratory Double-Blind, Parallel-Group, Randomized, Placebo-Controlled Trial

BMC Neurology (2020) 20:173.  Ethel Ciampi, Reinaldo Uribe-San-Martin, Claudia Cárcamo, Juan Pablo Cruz, , Ana Reyes, Diego Reyes, Carmen Pinto, Macarena Vásquez, Rafael A. Burgos and Juan Hancke

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203851/pdf/12883_2020_Article_1745.pdf

Andrographis Immune Health Research

  1. A Double Blind Study with a New Monodrug: Kan Jang Decrease of Symptoms and Enhancement of Resistance to Common Colds.

Phototherapy Research 9: 559- 562, 1995.  JL. Hancke et al.

  1. Prevention of common colds with Andrographis paniculata dried extract: A Pilot double blind trial

Phytomed. 4 (2), 101-104 (1997).  D.D. Cáceres et al.

https://www.sciencedirect.com/science/article/abs/pii/S0944711397800517?via%3Dihub

  1. Use of visual analogue scale measurements (VAS) to asses the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomized double blind-placebo study

Phytomedicine Volume 6, Issue 4, October 1999, Pages 217-223.  D.D.Cáceres, J.L.Hancke, R.A.Burgos, F.Sandberg, G.K.Wikman

https://www.sciencedirect.com/science/article/abs/pii/S0944711399800129?via%3Dihub

  1. Andrographolide As a Potential Inhibitor of SARS-CoV-2 Main Protease: An In Silico Approach

Journal of Biomolecular Structure and Dynamics, Apr 2020. Sukanth Kumar Enmozhi, Kavitha Raja, Irudhayasamy Sebastine, Tiruchirappalli, & Jerrine Joseph

https://www.tandfonline.com/doi/full/10.1080/07391102.2020.1760136

  1. Andrographis paniculata (Chuān Xīn LiaÂn) for symptomatic relief of acute respiratory tract infections in adults and children: A systematic review and meta-analysis

PLoS One. 2018; 13(11).  Xiao-Yang Hu, Ruo-Han Wu, Martin Logue, Clara Blondel, Lily Yuen Wan Lai, Beth Stuart, Andrew Flower, Yu-Tong Fei, Michael Moore, Jonathan Shepherd, Jian-Ping Liu, and George Lewith

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235384/

  1. Immunomodulatory activity of andrographolide on macrophage activation and specific antibody response.

Acta Pharmacol Sin. 2010 Feb; 31(2): 191–201. Wei Wang, Jing Wang, Sheng-fu Dong, Chun-hong Liu, Paola Italiani, Shu-hui Sun, Jing Xu, Diana Boraschi, Shi-ping Ma, and Di Qu

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002847/

Andrographis Anti-Viral Research

  1. Activity of Andrographolide and Its Derivatives against Influenza Virus in Vivo and in Vitro

Biological and Pharmaceutical.  Volume 32 (2009) Issue 8

Jian-Xin Chen, Hui-Jun Xue, Wen-Cai Ye, Bing-Hu Fang, Ya-Hong Liu, Shao-Hua Yuan, Pei Yu, Yu-Qiang Wang

https://www.jstage.jst.go.jp/article/bpb/32/8/32_8_1385/_article

  1. A Phase I Trial of Andrographolide in HIV Positive Patients and Normal Volunteers

Phytotherapy Research. Volume14, Issue5 August 2000

Pages 333-338.  Carlo Calabrese  Sheryl H. Berman  John G. Babish  Xinfang Ma  Lynne Shinto  Melissa Dorr  Kameron Wells  Cynthia A. Wenner  Leanna J. Standish

https://onlinelibrary.wiley.com/doi/abs/10.1002/1099-1573(200008)14:5%3C333::AID-PTR584%3E3.0.CO;2-D

  1. Activity of andrographolide against chikungunya virus infection

Scientific Report. 2015; 5: 14179.  Phitchayapak Wintachai, Parveen Kaur, Regina Ching Hua Lee, Suwipa Ramphan, Atichat Kuadkitkan, Nitwara Wikan, Sukathida Ubol, Sittiruk Roytrakul, Justin Jang Hann Chu, and Duncan R. Smith

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585663/

  1. Broad-spectrum antiviral properties of andrographolide

Archives of Virology 162(3) · November 2016.  Swati Gupta, K. P. Mishra.

https://www.researchgate.net/publication/311098110_Broad-spectrum_antiviral_properties_of_andrographolide

  1. Analyzing the interaction of a herbal compound Andrographolide from Andrographis paniculata as a folklore against swine flu (H1N1)

Asian Pac J Trop Dis. 2014 Sep; 4: S624–S630.  Chandrabhan Seniya, Shilpi Shrivastava, Sanjay Kumar Singh, and Ghulam Jilani Khan

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129870/

  1. Antiviral and Immunostimulant Activities of Andrographis paniculata

HAYATI Journal of Biosciences 22(2) · April 2015.    Churiyah, Elrade Rofaani, Olivia Bunga Pongtuluran 

https://www.researchgate.net/publication/307707579_Antiviral_and_Immunostimulant_Activities_of_Andrographis_paniculata

  1. Possible inhibitors of ACE2, the receptor of 2019-nCoV

Pharmacology & Toxicology February 2020.  Qinghua Cui, Chuanbo Huang, Xiangwen Ji, Wanlu Zhang, Fenghong Zhang, Liang Wang

https://www.preprints.org/manuscript/202002.0047/v1

  1. Computational Investigation on Andrographis paniculata Phytochemicals to Evaluate Their Potency Against SARS-CoV-2 in Comparison to Known Antiviral Compounds in Drug Trials.

JOURNAL OF BIOMOLECULAR STRUCTURE AND DYNAMICS May 2020. 

Natarajan Arul Murugan, Chitra Jeyaraj Pandian and Jeyaraman Jeyakanthan

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309306/pdf/TBSD_A_1777901.pdf

  1. Crosstalk Between Endoplasmic Reticulum Stress and Anti-Viral Activities: A Novel Therapeutic Target for COVID-19.

Life Science 2020 Aug 15; 255: 117842. 

Aditi Banerjee, Steven J. Czinn, Russel J. Reiter, and Thomas G. Blanchard

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245231/

Andrographis Lung Health Research

  1. Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity

British Journal of Pharmacology.  Volume168, Issue7 April 2013 Pages 1707-1718.

SP Guan,  W Tee,  DSW Ng,  TK Chan,  HY Peh,  WE Ho,  C Cheng,  JC Mak,  WSF Wong

https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.12054

  1. Andrographolide Protects against LPS-Induced Acute Lung Injury by Inactivation of NF-kB

PLoS One. 2013; 8(2).  Tao Zhu, Dao-xin Wang, Wei Zhang, Xiu-qing Liao, Xian Guan, Hong Bo, Jia-yang Sun,  Ni-wen Huang, Jing He, Yun-kun Zhang, Jing Tong, and Chang-yi Li

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578846/

  1. Cigarette Smoke-Induced Lung Disease Predisposes to More Severe Infection with Nontypeable Haemophilus influenzae: Protective Effects of Andrographolide

Journal of Natural Product. 2016, 79, 5, 1308–1315.  W. S. Daniel Tan, Hong Yong Peh, Wupeng Liao, Chu Hui Pang, Tze Khee Chan, Suk Hiang Lau, Vincent T. Chow, and W. S. Fred Wong

https://pubs.acs.org/doi/10.1021/acs.jnatprod.5b01006

  1. Andrographolide Restores Steroid Sensitivity To Block Lipopolysaccharide/IFN-γ–Induced IL-27 and Airway Hyperresponsiveness in Mice

J Immunol June 1, 2016, 196 (11) 4706-4712.  Wupeng Liao, W. S. Daniel Tan and W. S. Fred Wong

https://www.jimmunol.org/content/196/11/4706

  1. Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis

Cell Death & Disease volume 10, Article number: 957 (2019).  Jian Gao, Shuang Peng, Xinni Shan, Guoliang Deng, Lihong Shen, Jian Sun, Chunhong Jiang, Xiaoling Yang, Zhigang Chang, Xinchen Sun, Fude Feng, Lingdong Kong, Yanhong Gu, Wenjie Guo, Qiang Xu & Yang Sun

https://www.nature.com/articles/s41419-019-2195-8

  1. Restoration of HDAC2 and Nrf2 by Andrographolide Overcomes Corticosteroid Resistance in Chronic Obstructive Pulmonary Disease.

British Journal of Pharmacology. Apr 2020

Wupeng Liao,  Albert Y. H. Lim,  W. S. Daniel Tan,  John Abisheganaden,  W. S. Fred Wong

https://bpspubs.onlinelibrary.wiley.com/doi/epdf/10.1111/bph.15080

Andrographis Mechanism of Action Research

  1. Andrographolide interferes with binding of nuclear factor-κB to DNA in HL-60-derived neutrophilic cells

Br J Pharmacol. 2005 Mar; 144(5): 680–686.  María A Hidalgo, Alex Romero, Jaime Figueroa, Patricia Cortés, Ilona I Concha, Juan L Hancke, and Rafael A Burgos

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576048/pdf/144-0706105a.pdf

  1. Andrographolide Inhibits INF-g and IL-2 Cytokine Production and Protects against Cell Apoptosis. Planta Medica. 71 (5), 429-434 (2005).A. Burgos et al

https://pubmed.ncbi.nlm.nih.gov/15931581/

  1. Andrographolide Reduces IL-2 Production in T-Cells by Interfering with NFAT and MAPK Activation

Eur. J. Pharmacol. 602(2-3), 413–421 (2009).  María D Carretta, Pablo Alarcón, Evelyn Jara, Loreto Solis, Juan L Hancke, Ilona I Concha, María A Hidalgo, Rafael A Burgos

https://www.sciencedirect.com/science/article/abs/pii/S0014299908011278?via%3Dihub

  1. Is there a future for andrographolide to be an anti-inflammatory drug? Deciphering its major mechanisms of action

Biochem Pharmacol. 2017 Sep 1;139:71-81  W.S. Daniel, Tana Wupeng, Liaoa Shuo Zhoua, W.S. Fred Wong

https://www.sciencedirect.com/science/article/abs/pii/S0006295217301880?via%3Dihub

  1. Multi-Targeting Andrographolide, a Novel NF-kB Inhibitor, as a Potential Therapeutic Agent for Stroke.

Int J Mol Sci. 2017 Aug; 18(8): 1638.  Chih-Hao Yang, Ting-Lin Yen, Chia-Yuan Hsu, Philip-Aloysius Thomas, Joen-Rong Sheu, and Thanasekaran Jayakumar

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578028/

  1. Andrographolide, A Natural Antioxidant: An Update

Antioxidants 2019, 8, 571;  Eugenie Mussard, Annabelle Cesaro, Eric Lespessailles, Brigitte Legrain, Sabine Berteina-Raboin and Hechmi Toumi

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943416/pdf/antioxidants-08-00571.pdf

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